Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

Aberrant innate immune signaling in myelodysplastic syndrome (MDS) hematopoietic stem/progenitor cells (HSPCs) has been implicated as a driver of the development of MDS. We herein demonstrated that a prior stimulation with bacterial and viral products followed by loss of the Tet2 gene facilitated th...

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Detalles Bibliográficos
Autores principales: Yokomizo-Nakano, Takako, Hamashima, Ai, Kubota, Sho, Bai, Jie, Sorin, Supannika, Sun, Yuqi, Kikuchi, Kenta, Iimori, Mihoko, Morii, Mariko, Kanai, Akinori, Iwama, Atsushi, Huang, Gang, Kurotaki, Daisuke, Takizawa, Hitoshi, Matsui, Hirotaka, Sashida, Goro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120406/
https://www.ncbi.nlm.nih.gov/pubmed/37071125
http://dx.doi.org/10.1084/jem.20220962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120406/
https://www.ncbi.nlm.nih.gov/pubmed/37071125
http://dx.doi.org/10.1084/jem.20220962

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