Aromatic sulphonamides of aziridine-2-carboxylic acid derivatives as novel PDIA1 and PDIA3 inhibitors

In this study, we report a series of newly synthesised sulphonamides of aziridine-2-carboxylic acid (Az-COOH) ester and amide analogues as potent protein disulphide isomerase (PDI, EC 5.3.4.1) inhibitors. The inhibitory activity on PDI was determined against recombinant human PDIA1 and PDIA3 protein...

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Detalles Bibliográficos
Autores principales: Zelencova-Gopejenko, D., Andrianov, V., Domracheva, I., Kanepe-Lapsa, I., Milczarek, M., Stojak, M., Przyborowski, K., Fedak, F. A., Walczak, M., Kramkowski, K., Wietrzyk, J., Chlopicki, S., Kalvins, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120451/
https://www.ncbi.nlm.nih.gov/pubmed/37070480
http://dx.doi.org/10.1080/14756366.2022.2158187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120451/
https://www.ncbi.nlm.nih.gov/pubmed/37070480
http://dx.doi.org/10.1080/14756366.2022.2158187

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