“Stapling” scFv for multispecific biotherapeutics of superior properties

Single-chain fragment variable (scFv) domains play an important role in antibody-based therapeutic modalities, such as bispecifics, multispecifics and chimeric antigen receptor T cells or natural killer cells. However, scFv domains exhibit lower stability and increased risk of aggregation due to tra...

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Detalles Bibliográficos
Autores principales: Boucher, Lauren E., Prinslow, Elisabeth Geyer, Feldkamp, Michael, Yi, Fang, Nanjunda, Rupesh, Wu, Sheng-Jiun, Liu, Tun, Lacy, Eilyn R., Jacobs, Steven, Kozlyuk, Natalia, Del Rosario, Brian, Wu, Bingyuan, Aquino, Patricia, Davidson, Robert C., Heyne, Samantha, Mazzanti, Nicholas, Testa, James, Diem, Michael D., Gorre, Elsa, Mahan, Andrew, Nanda, Hirsh, Gunawardena, Harsha P., Gervais, Alexis, Armstrong, Anthony A., Teplyakov, Alexey, Huang, Chichi, Zwolak, Adam, Chowdhury, Partha, Cheung, Wan Cheung, Luo, Jinquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120459/
https://www.ncbi.nlm.nih.gov/pubmed/37074212
http://dx.doi.org/10.1080/19420862.2023.2195517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120459/
https://www.ncbi.nlm.nih.gov/pubmed/37074212
http://dx.doi.org/10.1080/19420862.2023.2195517

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