Cargando…

CARD9 deficiency promotes pancreatic cancer growth by blocking dendritic cell maturation via SLC6A8-mediated creatine transport

Pancreatic cancer (PC) is featured with low survival rate and poor outcomes. Herein, we found that the expression of caspase-recruitment domain-containing protein 9 (CARD9), predominantly expressed in innate immune cells, was positively related to the prognosis of PC patients. CARD9-deficient PC mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tian, Cheng, Yuan, Huimin, Lu, Yi, He, Henghui, Li, Qing, Li, Senlin, Yang, Jian, Wang, Mengheng, Xu, Ruochen, Liu, Qian, Xiang, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120541/ https://www.ncbi.nlm.nih.gov/pubmed/37089447 http://dx.doi.org/10.1080/2162402X.2023.2204015

Ejemplares similares

Treatment efficacy of high‐dose creatine supplementation in a child with creatine transporter (SLC6A8) deficiency
por: Shi, Kaili, et al.
Publicado: (2021)

Creatine Transporter (CrT; Slc6a8) Knockout Mice as a Model of Human CrT Deficiency
por: Skelton, Matthew R., et al.
Publicado: (2011)

The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency Syndrome
por: Farr, Clemens V., et al.
Publicado: (2020)

Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle
por: Russell, Aaron P., et al.
Publicado: (2014)

Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels
por: Kurth, Isabel, et al.
Publicado: (2021)

Changes in creatine transporter function during cardiac maturation in the rat
por: Fischer, Alexandra, et al.
Publicado: (2010)

A novel SLC6A8 mutation associated with motor dysfunction in a child exhibiting creatine transporter deficiency
por: Cervera-Acedo, Cristina, et al.
Publicado: (2015)

A novel mouse model of creatine transporter deficiency
por: Baroncelli, Laura, et al.
Publicado: (2014)

Creatine transporter deficiency: Novel mutations and functional studies
por: Ardon, O., et al.
Publicado: (2016)

Novel translational phenotypes and biomarkers for creatine transporter deficiency
por: Mazziotti, Raffaele, et al.
Publicado: (2020)

A novel SLC6A8 mutation associated with intellectual disabilities in a Chinese family exhibiting creatine transporter deficiency: case report
por: Wang, Qin, et al.
Publicado: (2018)

Creatine transporter–deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy
por: Duran‐Trio, Lara, et al.
Publicado: (2021)

Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis
por: Chen, Hong-Ru, et al.
Publicado: (2021)

Diagnosis and Treatment of X-Linked Creatine Transporter Deficiency: Case Report and Literature Review
por: Li, Jiaqing, et al.
Publicado: (2023)

Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer
por: Zhou, Zhongshi, et al.
Publicado: (2019)

The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males
por: Andre, Tom, et al.
Publicado: (2015)

The Role of CARD9 Deficiency in Neutrophils
por: Sheng, Ruanmei, et al.
Publicado: (2021)

Studies of structural determinants of substrate binding in the Creatine Transporter (CreaT, SLC6A8) using molecular models
por: Colas, Claire, et al.
Publicado: (2020)

Creatine deficiency and heart failure
por: Del Franco, Annamaria, et al.
Publicado: (2021)

Neuropsychological profile and clinical effects of arginine treatment in children with creatine transport deficiency
por: Chilosi, Annamaria, et al.
Publicado: (2012)

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts
por: Gorshkov, Kirill, et al.
Publicado: (2019)

Creatine salts provide neuroprotection even after partial impairment of the creatine transporter
por: Adriano, E., et al.
Publicado: (2017)

The Role of Preclinical Models in Creatine Transporter Deficiency: Neurobiological Mechanisms, Biomarkers and Therapeutic Development
por: Ghirardini, Elsa, et al.
Publicado: (2021)

When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters
por: Sucic, Sonja, et al.
Publicado: (2016)

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice
por: Xin, Yongjuan, et al.
Publicado: (2017)

Creatine Transporter Deficiency Presenting as Failure to Thrive: A Case Report of a Novel SLC6A8 Variant Causing a Treatable but Likely Underdiagnosed Genetic Disorder
por: Tise, Christina G., et al.
Publicado: (2023)

The Regulation and Expression of the Creatine Transporter: A Brief Review of Creatine Supplementation in Humans and Animals
por: Schoch, Ryan D, et al.
Publicado: (2006)

Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models
por: Kim, Dae Won, et al.
Publicado: (2010)

Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency
por: Rahhal, Samar, et al.
Publicado: (2023)

Rare disease variant curation from literature: assessing gaps with creatine transport deficiency in focus
por: Lyons, Erica L., et al.
Publicado: (2023)

The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neurons
por: Lin, Wen-Yang, et al.
Publicado: (2015)

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism
por: Stockebrand, Malte, et al.
Publicado: (2018)

Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency
por: Cacciante, Francesco, et al.
Publicado: (2020)

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism
por: Duran-Trio, Lara, et al.
Publicado: (2021)

Effects of Delivering Guanidinoacetic Acid or Its Prodrug to the Neural Tissue: Possible Relevance for Creatine Transporter Deficiency
por: Adriano, Enrico, et al.
Publicado: (2022)

Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency
por: Ghirardini, Elsa, et al.
Publicado: (2023)

Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse
por: Ireland, Zoe, et al.
Publicado: (2009)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction
por: Lygate, Craig A., et al.
Publicado: (2012)

Effect of SNPs on Creatine Kinase Structure and Function: Identifying Potential Molecular Mechanisms for Possible Creatine Kinase Deficiency Diseases
por: Li, Chang, et al.
Publicado: (2012)

Loss of Slc26a9 anion transporter alters intestinal electrolyte and HCO(3)(-) transport and reduces survival in CFTR-deficient mice
por: Liu, Xuemei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0c7ip8smbgh1dlmt2laemiei49