Computational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to autocleavage

Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that remodels the extracellular matrix and has been implicated as a major driver in cancer metastasis. Hence, there is a high demand for MMP-9 inhibitors for therapeutic purposes. For such drug design efforts, large amounts of MMP-9 are required...

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Detalles Bibliográficos
Autores principales: Bonadio, Alessandro, Oguche, Solomon, Lavy, Tali, Kleifeld, Oded, Shifman, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120622/
https://www.ncbi.nlm.nih.gov/pubmed/37090502
http://dx.doi.org/10.1101/2023.04.11.536383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120622/
https://www.ncbi.nlm.nih.gov/pubmed/37090502
http://dx.doi.org/10.1101/2023.04.11.536383

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