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Computational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to autocleavage

Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that remodels the extracellular matrix and has been implicated as a major driver in cancer metastasis. Hence, there is a high demand for MMP-9 inhibitors for therapeutic purposes. For such drug design efforts, large amounts of MMP-9 are required...

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Detalles Bibliográficos
Autores principales:	Bonadio, Alessandro, Oguche, Solomon, Lavy, Tali, Kleifeld, Oded, Shifman, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120622/ https://www.ncbi.nlm.nih.gov/pubmed/37090502 http://dx.doi.org/10.1101/2023.04.11.536383

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