MUSSEL: Enhanced Bayesian Polygenic Risk Prediction Leveraging Information across Multiple Ancestry Groups

Polygenic risk scores (PRS) are now showing promising predictive performance on a wide variety of complex traits and diseases, but there exists a substantial performance gap across different populations. We propose MUSSEL, a method for ancestry-specific polygenic prediction that borrows information...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Jin, Zhan, Jianan, Zhang, Jingning, Zhao, Ruzhang, O’Connell, Jared, Jiang, Yunxuan, Buyske, Steven, Gignoux, Christopher, Haiman, Christopher, Kenny, Eimear E., Kooperberg, Charles, North, Kari, Koelsch, Bertram L., Wojcik, Genevieve, Zhang, Haoyu, Chatterjee, Nilanjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120638/
https://www.ncbi.nlm.nih.gov/pubmed/37090648
http://dx.doi.org/10.1101/2023.04.12.536510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120638/
https://www.ncbi.nlm.nih.gov/pubmed/37090648
http://dx.doi.org/10.1101/2023.04.12.536510

Ejemplares similares