Cargando…

MUSSEL: Enhanced Bayesian Polygenic Risk Prediction Leveraging Information across Multiple Ancestry Groups

Polygenic risk scores (PRS) are now showing promising predictive performance on a wide variety of complex traits and diseases, but there exists a substantial performance gap across different populations. We propose MUSSEL, a method for ancestry-specific polygenic prediction that borrows information...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Jin, Zhan, Jianan, Zhang, Jingning, Zhao, Ruzhang, O’Connell, Jared, Jiang, Yunxuan, Buyske, Steven, Gignoux, Christopher, Haiman, Christopher, Kenny, Eimear E., Kooperberg, Charles, North, Kari, Koelsch, Bertram L., Wojcik, Genevieve, Zhang, Haoyu, Chatterjee, Nilanjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120638/ https://www.ncbi.nlm.nih.gov/pubmed/37090648 http://dx.doi.org/10.1101/2023.04.12.536510

Ejemplares similares

An Ensemble Penalized Regression Method for Multi-ancestry Polygenic Risk Prediction
por: Zhang, Jingning, et al.
Publicado: (2023)

Estimating heritability explained by local ancestry and evaluating stratification bias in admixture mapping from summary statistics
por: Chan, Tsz Fung, et al.
Publicado: (2023)

Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries
por: Smith, Samuel Pattillo, et al.
Publicado: (2022)

The role of country of birth, and genetic and self-identified ancestry, in obesity susceptibility among African and Hispanic Americans
por: Vishnu, Abhishek, et al.
Publicado: (2019)

Leveraging Multi-Ancestry Polygenic Risk Scores for Body Mass Index to Predict Antiretroviral Therapy-Induced Weight Gain*
por: Keat, Karl, et al.
Publicado: (2023)

On cross-ancestry cancer polygenic risk scores
por: Fritsche, Lars G., et al.
Publicado: (2021)

Polygenic Risk for Insomnia in Adolescents of Diverse Ancestry
por: Ma, Tengfei, et al.
Publicado: (2021)

Improving polygenic prediction with genetically inferred ancestry
por: Naret, Olivier, et al.
Publicado: (2022)

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
por: Carlson, Christopher S., et al.
Publicado: (2013)

Leveraging genetic ancestry to study health disparities
por: Batai, Ken, et al.
Publicado: (2020)

Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults
por: Deng, Wei Q., et al.
Publicado: (2023)

Variable prediction accuracy of polygenic scores within an ancestry group
por: Mostafavi, Hakhamanesh, et al.
Publicado: (2020)

Polygenic scoring accuracy varies across the genetic ancestry continuum
por: Ding, Yi, et al.
Publicado: (2023)

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations
por: Yoneyama, Sachiko, et al.
Publicado: (2016)

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
por: Liang, Yanyu, et al.
Publicado: (2022)

Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study
por: Lin, Bridget M., et al.
Publicado: (2019)

Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array
por: Bien, Stephanie A., et al.
Publicado: (2016)

Performance of African-ancestry-specific polygenic hazard score varies according to local ancestry in 8q24
por: Karunamuni, Roshan A., et al.
Publicado: (2022)

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
por: Wang, Ying, et al.
Publicado: (2020)

Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology
por: Wang, Ying, et al.
Publicado: (2023)

Polygenic Risk Assessment Reveals Pleiotropy between Sarcoidosis and Inflammatory Disorders in the Context of Genetic Ancestry
por: Lareau, Caleb A., et al.
Publicado: (2017)

Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score
por: Huynh-Le, Minh-Phuong, et al.
Publicado: (2022)

Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
por: Kim, Michelle S., et al.
Publicado: (2022)

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations
por: Ge, Tian, et al.
Publicado: (2022)

Polygenic risk score prediction of multiple sclerosis in individuals of South Asian ancestry
por: Breedon, Joshua R, et al.
Publicado: (2023)

Optimal strategies for learning multi-ancestry polygenic scores vary across traits
por: Lehmann, Brieuc, et al.
Publicado: (2023)

Predictive performance of polygenic scores for coronary artery disease in multiple genetic ancestries
por: Regazzi, L, et al.
Publicado: (2023)

Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry
por: Darst, Burcu F., et al.
Publicado: (2023)

Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics
por: Hodonsky, Chani J., et al.
Publicado: (2020)

IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score
por: Tang, Yingdan, et al.
Publicado: (2022)

Evaluation of optimal methods and ancestries for calculating polygenic risk scores in East Asian population
por: Kim, Dong Jun, et al.
Publicado: (2023)

Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes
por: Tubbs, Justin D., et al.
Publicado: (2023)

Ancestry-specific polygenic risk scores are risk enhancers for clinical cardiovascular disease assessments
por: Busby, George B., et al.
Publicado: (2023)

Analysis of ancestry-specific polygenic risk score and diet composition in type 2 diabetes
por: Hardy, Dale S., et al.
Publicado: (2023)

Leveraging local ancestry to detect gene-gene interactions in genome-wide data
por: Aschard, Hugues, et al.
Publicado: (2015)

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations
por: Chen, Fei, et al.
Publicado: (2022)

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals
por: Marnetto, Davide, et al.
Publicado: (2020)

Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry
por: Liu, Cong, et al.
Publicado: (2021)

Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition
por: Hughes, Elisha, et al.
Publicado: (2022)

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity
por: Smith, Kirk, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qtn9vv6hvqhpopf9uluu1o8vik