Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

Type 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb). To kill Mtb, Ndh-2 needs to be inactivated together with the alternative enzyme type 1 NADH dehy...

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Detalles Bibliográficos
Autores principales: Xu, Yuanyuan, Ehrt, Sabine, Schnappinger, Dirk, Beites, Tiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120654/
https://www.ncbi.nlm.nih.gov/pubmed/37090679
http://dx.doi.org/10.1101/2023.04.10.536268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120654/
https://www.ncbi.nlm.nih.gov/pubmed/37090679
http://dx.doi.org/10.1101/2023.04.10.536268

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