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Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

Type 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb). To kill Mtb, Ndh-2 needs to be inactivated together with the alternative enzyme type 1 NADH dehy...

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Detalles Bibliográficos
Autores principales:	Xu, Yuanyuan, Ehrt, Sabine, Schnappinger, Dirk, Beites, Tiago
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120654/ https://www.ncbi.nlm.nih.gov/pubmed/37090679 http://dx.doi.org/10.1101/2023.04.10.536268

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