Single-cell DNA replication dynamics in genomically unstable cancers

Dysregulated DNA replication is both a cause and a consequence of aneuploidy, yet the dynamics of DNA replication in aneuploid cell populations remains understudied. We developed a new method, PERT, for inferring cell-specific DNA replication states from single-cell whole genome sequencing, and inve...

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Detalles Bibliográficos
Autores principales: Weiner, Adam C., Williams, Marc J., Shi, Hongyu, Vázquez-García, Ignacio, Salehi, Sohrab, Rusk, Nicole, Aparicio, Samuel, Shah, Sohrab P., McPherson, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120671/
https://www.ncbi.nlm.nih.gov/pubmed/37090647
http://dx.doi.org/10.1101/2023.04.10.536250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120671/
https://www.ncbi.nlm.nih.gov/pubmed/37090647
http://dx.doi.org/10.1101/2023.04.10.536250

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