OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence

Telomeres are prone to formation of the common oxidative lesion 8-oxoguanine (8oxoG), and the acute production of 8oxoG damage at telomeres is sufficient to drive rapid cellular senescence. OGG1 and MUTYH glycosylases initiate base excision repair (BER) at 8oxoG sites to remove the lesion or prevent...

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Detalles Bibliográficos
Autores principales: De Rosa, Mariarosaria, Barnes, Ryan P., Nyalapatla, Prasanth R., Wipf, Peter, Opresko, Patricia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120708/
https://www.ncbi.nlm.nih.gov/pubmed/37090589
http://dx.doi.org/10.1101/2023.04.10.536247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120708/
https://www.ncbi.nlm.nih.gov/pubmed/37090589
http://dx.doi.org/10.1101/2023.04.10.536247

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