Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination

ATP-dependent DNA ligases catalyze phosphodiester bond formation in the conserved three-step chemical reaction of nick sealing. Human DNA ligase I (LIG1) finalizes almost all DNA repair pathways following DNA polymerase-mediated nucleotide insertion. We previously reported that LIG1 discriminates mi...

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Detalles Bibliográficos
Autores principales: Gulkis, Mitchell, Tang, Qun, Petrides, Matthew, Çağlayan, Melike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120772/
https://www.ncbi.nlm.nih.gov/pubmed/37090517
http://dx.doi.org/10.21203/rs.3.rs-2720903/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120772/
https://www.ncbi.nlm.nih.gov/pubmed/37090517
http://dx.doi.org/10.21203/rs.3.rs-2720903/v1

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