Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival

BACKGROUND AND AIMS: The microbiome has long been suspected of a role in colorectal cancer (CRC) tumorigenesis. The mutational signature SBS88 mechanistically links CRC development with the strain of Escherichia coli harboring the pks island that produces the genotoxin colibactin, but the genomic, p...

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Detalles Bibliográficos
Autores principales: Georgeson, Peter, Steinfelder, Robert S., Harrison, Tabitha A., Pope, Bernard J., Zaidi, Syed H., Qu, Conghui, Lin, Yi, Joo, Jihoon E., Mahmood, Khalid, Clendenning, Mark, Walker, Romy, Aglago, Elom K, Berndt, Sonja I., Brenner, Hermann, Campbell, Peter T., Cao, Yin, Chan, Andrew T., Chang-Claude, Jenny, Dimou, Niki, Doheny, Kimberly F., Drew, David A., Figueiredo, Jane C., French, Amy J., Gallinger, Steven, Giannakis, Marios, Giles, Graham G., Goode, Ellen L, Gruber, Stephen B, Gsur, Andrea, Gunter, Marc J., Harlid, Sophia, Hoffmeister, Michael, Hsu, Li, Huang, Wen-Yi, Huyghe, Jeroen R, Manson, JoAnn E., Moreno, Victor, Murphy, Neil, Nassir, Rami, Newton, Christina C., Nowak, Jonathan A., Obón-Santacana, Mireia, Ogino, Shuji, Pai, Rish K., Papadimitrou, Nikos, Potter, John D., Schoen, Robert E., Song, Mingyang, Sun, Wei, Toland, Amanda E., Trinh, Quang M., Tsilidis, Kostas, Ugai, Tomotaka, Um, Caroline Y, Macrae, Finlay A., Rosty, Christophe, Hudson, Thomas J., Winship, Ingrid M., Phipps, Amanda I., Jenkins, Mark A., Peters, Ulrike, Buchanan, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120801/
https://www.ncbi.nlm.nih.gov/pubmed/37090539
http://dx.doi.org/10.1101/2023.03.10.23287127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10120801/
https://www.ncbi.nlm.nih.gov/pubmed/37090539
http://dx.doi.org/10.1101/2023.03.10.23287127

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