Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration

Although microglial activation is widely found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the underlying mechanism(s) are poorly understood. Here, using human-induced pluripotent stem cell–derived microglia-like cells (hiPSC-MG) harboring the most common ALS/FTD mutati...

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Detalles Bibliográficos
Autores principales: Banerjee, Poulomi, Mehta, Arpan R., Nirujogi, Raja S., Cooper, James, James, Owen G., Nanda, Jyoti, Longden, James, Burr, Karen, McDade, Karina, Salzinger, Andrea, Paza, Evdokia, Newton, Judith, Story, David, Pal, Suvankar, Smith, Colin, Alessi, Dario R., Selvaraj, Bhuvaneish T., Priller, Josef, Chandran, Siddharthan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121169/
https://www.ncbi.nlm.nih.gov/pubmed/37083530
http://dx.doi.org/10.1126/sciadv.abq0651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121169/
https://www.ncbi.nlm.nih.gov/pubmed/37083530
http://dx.doi.org/10.1126/sciadv.abq0651

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