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The influence of excipients on the viscosity of monoclonal antibody solutions
The aggregation propensity of monoclonal antibodies can be modified by adding different cosolutes into the solution. A simple coarse-grained model in the combination with the thermodynamic perturbation theory was used to predict cluster distribution and viscosity of the solutions of IgG4 monoclonal...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121187/ https://www.ncbi.nlm.nih.gov/pubmed/37089876 http://dx.doi.org/10.1016/j.molliq.2022.120349 |