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Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use

This perspective summarizes available evidence on biomarkers of exposure in electronic nicotine delivery system (ENDS) users to aid the overall assessment of the health consequences of using ENDS. Identification of novel biomarkers of exposure specific to ENDS use remains challenging because chemica...

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Autor principal: Goniewicz, Maciej L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121191/
https://www.ncbi.nlm.nih.gov/pubmed/37089248
http://dx.doi.org/10.1016/j.addicn.2023.100077
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author Goniewicz, Maciej L.
author_facet Goniewicz, Maciej L.
author_sort Goniewicz, Maciej L.
collection PubMed
description This perspective summarizes available evidence on biomarkers of exposure in electronic nicotine delivery system (ENDS) users to aid the overall assessment of the health consequences of using ENDS. Identification of novel biomarkers of exposure specific to ENDS use remains challenging because chemicals emitted from ENDS devices have many familiar sources. The biomarker levels of many tobacco-related toxicants measured in biological samples collected from ENDS users did not differ significantly from non-users, except for nicotine metabolites and a small number of biomarkers of exposure to volatile organic compounds and tobacco-specific tobacco nitrosamines. Several studies have shown that while exposed to nicotine, long-term exclusive ENDS users showed significantly lower levels of toxicant biomarkers than cigarette smokers. Studies have also shown that concurrent users of ENDS and combustible cigarettes (‘dual users’) are not reducing overall exposure to harmful toxicants compared to exclusive cigarette smokers. Because of an absence of validated ENDS-specific biomarkers, we recommend combining several biomarkers to differentiate tobacco product user groups in population-based studies and monitor ENDS compliance in randomized controlled trials. Using a panel of biomarkers would provide a better understanding of health effects related to ENDS use.
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spelling pubmed-101211912023-06-01 Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use Goniewicz, Maciej L. Addict Neurosci Article This perspective summarizes available evidence on biomarkers of exposure in electronic nicotine delivery system (ENDS) users to aid the overall assessment of the health consequences of using ENDS. Identification of novel biomarkers of exposure specific to ENDS use remains challenging because chemicals emitted from ENDS devices have many familiar sources. The biomarker levels of many tobacco-related toxicants measured in biological samples collected from ENDS users did not differ significantly from non-users, except for nicotine metabolites and a small number of biomarkers of exposure to volatile organic compounds and tobacco-specific tobacco nitrosamines. Several studies have shown that while exposed to nicotine, long-term exclusive ENDS users showed significantly lower levels of toxicant biomarkers than cigarette smokers. Studies have also shown that concurrent users of ENDS and combustible cigarettes (‘dual users’) are not reducing overall exposure to harmful toxicants compared to exclusive cigarette smokers. Because of an absence of validated ENDS-specific biomarkers, we recommend combining several biomarkers to differentiate tobacco product user groups in population-based studies and monitor ENDS compliance in randomized controlled trials. Using a panel of biomarkers would provide a better understanding of health effects related to ENDS use. 2023-06 2023-02-26 /pmc/articles/PMC10121191/ /pubmed/37089248 http://dx.doi.org/10.1016/j.addicn.2023.100077 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Article
Goniewicz, Maciej L.
Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use
title Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use
title_full Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use
title_fullStr Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use
title_full_unstemmed Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use
title_short Biomarkers of Electronic Nicotine Delivery Systems (ENDS) use
title_sort biomarkers of electronic nicotine delivery systems (ends) use
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121191/
https://www.ncbi.nlm.nih.gov/pubmed/37089248
http://dx.doi.org/10.1016/j.addicn.2023.100077
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