Cargando…
The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease
The dark pigment neuromelanin (NM) is abundant in cell bodies of dopamine (DA) neurons in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in the human brain. During the progression of Parkinson’s disease (PD), together with the degeneration of the respective cat...
Autores principales: | Nagatsu, Toshiharu, Nakashima, Akira, Watanabe, Hirohisa, Ito, Shosuke, Wakamatsu, Kazumasa, Zucca, Fabio A., Zecca, Luigi, Youdim, Moussa, Wulf, Maximilian, Riederer, Peter, Dijkstra, Johannes M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121510/ https://www.ncbi.nlm.nih.gov/pubmed/36939908 http://dx.doi.org/10.1007/s00702-023-02617-6 |
Ejemplares similares
-
Neuromelanin in Parkinson’s Disease: Tyrosine Hydroxylase and Tyrosinase
por: Nagatsu, Toshiharu, et al.
Publicado: (2022) -
Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson’s disease
por: Riederer, Peter, et al.
Publicado: (2023) -
Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
por: Wulf, Maximilian, et al.
Publicado: (2022) -
Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus
por: Wakamatsu, Kazumasa, et al.
Publicado: (2015) -
Neuromelanins of Human Brain Have Soluble and Insoluble Components with Dolichols Attached to the Melanic Structure
por: Engelen, Mireille, et al.
Publicado: (2012)