Cargando…

Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes

Twin studies indicate that 30–40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGS(BD)) and clinical- (PGS(MDD)) depression summary statistics from the UK Biobank in an independent...

Descripción completa

Detalles Bibliográficos
Autores principales:	McGeary, John E., Benca-Bachman, Chelsie E., Risner, Victoria A., Beevers, Christopher G., Gibb, Brandon E., Palmer, Rohan H. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121555/ https://www.ncbi.nlm.nih.gov/pubmed/37085695 http://dx.doi.org/10.1038/s41598-023-33645-7

Ejemplares similares

Identifying genetic predictors of depression risk: 5-HTTLPR and BDNF Val66Met polymorphisms are associated with rumination and co-rumination in adolescents
por: Stone, Lindsey B., et al.
Publicado: (2013)

Risk for alcohol use/misuse among entering college students: The role of personality and stress
por: Martin, Kathleen P., et al.
Publicado: (2020)

Synchronised transcranial magnetic stimulation for substance use-disordered Veterans: protocol for the pilot sham-controlled acceptability trial
por: Jampel, Jonathan, et al.
Publicado: (2023)

Multi-omic and multi-species meta-analyses of nicotine consumption
por: Palmer, Rohan H. C., et al.
Publicado: (2021)

Genome- and transcriptome-wide splicing associations with alcohol use disorder
por: Huggett, Spencer B., et al.
Publicado: (2023)

Adolescent Behavioral Characteristics Mediate Familial Effects on Alcohol Use and Problems in College-Bound Students
por: Brown, April L, et al.
Publicado: (2020)

Genetic associations among internalizing and externalizing traits with polysubstance use among young adults
por: Brick, Leslie A, et al.
Publicado: (2023)

Inclusion of genetic variants in an ensemble of gradient boosting decision trees does not improve the prediction of citalopram treatment response
por: Shumake, Jason, et al.
Publicado: (2021)

Genome-wide polygenic scoring for a 14-year long-term average depression phenotype
por: Chang, Shun-Chiao, et al.
Publicado: (2014)

Predictors of Relapse in a Bupropion Trial for Smoking Cessation in Recently-Abstinent Alcoholics: Preliminary Results Using an Aggregate Genetic Risk Score
por: McGeary, John E., et al.
Publicado: (2012)

Polygenic risk score, healthy lifestyles, and risk of incident depression
por: Cao, Zhi, et al.
Publicado: (2021)

Association of schizophrenia polygenic risk score with manic and depressive psychosis in bipolar disorder
por: Markota, Matej, et al.
Publicado: (2018)

Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences
por: Rosenberg, Noah A, et al.
Publicado: (2018)

Combining Polygenic Risk Score and Voice Features to Detect Major Depressive Disorders
por: Di, Yazheng, et al.
Publicado: (2021)

Polygenic risk scores of lithium response and treatment resistance in major depressive disorder
por: Xiong, Ying, et al.
Publicado: (2023)

Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries
por: Liang, Yanyu, et al.
Publicado: (2022)

Risk Factors, Clinical Features, and Polygenic Risk Scores in Schizophrenia and Schizoaffective Disorder Depressive-Type
por: Dennison, Charlotte A, et al.
Publicado: (2021)

Polygenicity of Comorbid Depression in Multiple Sclerosis
por: Kowalec, Kaarina, et al.
Publicado: (2023)

Negative self-referential processing is associated with genetic variation in the serotonin transporter-linked polymorphic region (5-HTTLPR): Evidence from two independent studies
por: Dainer-Best, Justin, et al.
Publicado: (2018)

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
por: Whalley, H C, et al.
Publicado: (2016)

Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer’s Disease Based on Major Depressive Disorder Risk Variants
por: Upadhya, Suraj, et al.
Publicado: (2022)

Depressive symptom trajectories and polygenic risk scores in individuals with an immune-mediated inflammatory disease
por: Kowalec, Kaarina, et al.
Publicado: (2022)

Affective temperament polygenic risk scores predict depression: investigating the role of environmental factors
por: Győrik, D., et al.
Publicado: (2023)

A Combined Effect of Polygenic Scores and Environmental Factors on Individual Differences in Depression Level
por: Kazantseva, Anastasiya, et al.
Publicado: (2023)

Specificity of Psychiatric Polygenic Risk Scores and Their Effects on Associated Risk Phenotypes
por: Rodrigue, Amanda L., et al.
Publicado: (2022)

A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism
por: Cheng, Bolun, et al.
Publicado: (2022)

Opioid Use Disorder and Alternative mRNA Splicing in Reward Circuitry
por: Huggett, Spencer B., et al.
Publicado: (2022)

Polygenic interactions with environmental adversity in the aetiology of major depressive disorder
por: Mullins, N., et al.
Publicado: (2016)

Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder
por: Amare, Azmeraw T., et al.
Publicado: (2018)

Headaches and polygenic scores
por: Vilhjálmsson, Bjarni J., et al.
Publicado: (2019)

Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis
por: Melhuish Beaupre, Lindsay M., et al.
Publicado: (2021)

Associations of cigarette smoking with gray and white matter in the UK Biobank
por: Gray, Joshua C., et al.
Publicado: (2020)

Complex pain phenotypes: Suicidal ideation and attempt through latent multimorbidity
por: Song, Kangwon, et al.
Publicado: (2022)

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
por: de Jong, Simone, et al.
Publicado: (2018)

Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
por: Schubert, Klaus Oliver, et al.
Publicado: (2021)

Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count
por: Sealock, Julia M., et al.
Publicado: (2021)

Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene–environment correlation
por: Machlitt‐Northen, Sandra, et al.
Publicado: (2022)

Telomere Length Associations With Clinical Diagnosis, Age, and Polygenic Risk Scores for Anxiety Disorder, Depression, and Bipolar Disorder
por: Mutz, Julian, et al.
Publicado: (2022)

Polygenic Risk for Major Depression Interacts with Parental Criticism in Predicting Adolescent Depressive Symptom Development
por: Nelemans, Stefanie A., et al.
Publicado: (2020)

Polygenic loading for major depression is associated with specific medical comorbidity
por: McCoy, T H, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pm6vjq8t84esb5gsscms892kmf