Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury

Irinotecan is a topoisomerase I inhibitor which has been widely used to combat several solid tumors, whereas irinotecan therapy can induce liver injury. Liver injury generally leads to tissue hypoxia, and hypoxia-inducible factor-1α (HIF-1α), a pivotal transcription factor, mediates adaptive pathoph...

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Detalles Bibliográficos
Autores principales: Shi, Congjian, Zhang, Zhenghong, Xu, Renfeng, Zhang, Yan, Wang, Zhengchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121580/
https://www.ncbi.nlm.nih.gov/pubmed/37085612
http://dx.doi.org/10.1038/s41598-023-33848-y