Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells

Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates V(H)-DJ(H) recombination following downregulation of the cohesin-release factor Wapl by Pax5, resulting in global changes in the chromosomal architecture of pro-B cells. Here, we demonstrate that chromatin looping...

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Detalles Bibliográficos
Autores principales: Hill, Louisa, Wutz, Gordana, Jaritz, Markus, Tagoh, Hiromi, Calderón, Lesly, Peters, Jan-Michael, Goloborodko, Anton, Busslinger, Meinrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121685/
https://www.ncbi.nlm.nih.gov/pubmed/37085514
http://dx.doi.org/10.1038/s41467-023-37994-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121685/
https://www.ncbi.nlm.nih.gov/pubmed/37085514
http://dx.doi.org/10.1038/s41467-023-37994-9

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