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Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells
Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates V(H)-DJ(H) recombination following downregulation of the cohesin-release factor Wapl by Pax5, resulting in global changes in the chromosomal architecture of pro-B cells. Here, we demonstrate that chromatin looping...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10121685/ https://www.ncbi.nlm.nih.gov/pubmed/37085514 http://dx.doi.org/10.1038/s41467-023-37994-9 |