DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis and carcinogenic potential in the colon of mice

BACKGROUND: Chronic inflammation induces DNA damage and promotes cell proliferation, thereby increasing the risk of cancer. DNA polymerase κ (Pol κ), involved in translesion DNA synthesis, counteracts mutagenesis induced by inflammation in the colon of mice. In the present study, we examined whether...

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Detalles Bibliográficos
Autores principales: Hakura, Atsushi, Sui, Hajime, Seki, Yuki, Sonoda, Jiro, Yoshida, Yusaku, Takagi, Hisayoshi, Yokose, Shigeo, Matsuda, Tomonari, Asakura, Shoji, Nohmi, Takehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122296/
https://www.ncbi.nlm.nih.gov/pubmed/37087526
http://dx.doi.org/10.1186/s41021-023-00272-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122296/
https://www.ncbi.nlm.nih.gov/pubmed/37087526
http://dx.doi.org/10.1186/s41021-023-00272-7

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