A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer

BACKGROUND: Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and aberrant cholesterol metabolism in colorectal cancer (CRC) remains elusive. METHODS: Hypoxia-responsive circular RNAs (circRNAs) were iden...

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Detalles Bibliográficos
Autores principales: Xiong, Li, Liu, Hua-shan, Zhou, Chi, Yang, Xin, Huang, Liang, Jie, Hai-qing, Zeng, Zi-wei, Zheng, Xiao-bin, Li, Wen-xin, Liu, Zhan-zhen, Kang, Liang, Liang, Zhen-xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122405/
https://www.ncbi.nlm.nih.gov/pubmed/37087475
http://dx.doi.org/10.1186/s12943-023-01773-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122405/
https://www.ncbi.nlm.nih.gov/pubmed/37087475
http://dx.doi.org/10.1186/s12943-023-01773-3

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