TR-FRET-Based Immunoassay to Measure Ataxin-2 as a Target Engagement Marker in Spinocerebellar Ataxia Type 2

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited neurodegenerative disease, which belongs to the trinucleotide repeat disease group with a CAG repeat expansion in exon 1 of the ATXN2 gene resulting in an ataxin-2 protein with an expanded polyglutamine (polyQ)-stretch. The di...

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Detalles Bibliográficos
Autores principales: Bux, Jessica, Sen, Nesli Ece, Klink, Isa-Maria, Hauser, Stefan, Synofzik, Matthis, Schöls, Ludger, Auburger, Georg, Riess, Olaf, Hübener-Schmid, Jeannette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122633/
https://www.ncbi.nlm.nih.gov/pubmed/36894829
http://dx.doi.org/10.1007/s12035-023-03294-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122633/
https://www.ncbi.nlm.nih.gov/pubmed/36894829
http://dx.doi.org/10.1007/s12035-023-03294-y

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