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Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation
ABSTRACT: Alzheimer’s disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins induce synaptic dysfunctions that are strongly correlated with cognitive decline. Intracerebral infusion o...
Autores principales: | Célestine, Marina, Jacquier-Sarlin, Muriel, Borel, Eve, Petit, Fanny, Perot, Jean-Baptiste, Hérard, Anne-Sophie, Bousset, Luc, Buisson, Alain, Dhenain, Marc |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122826/ https://www.ncbi.nlm.nih.gov/pubmed/37087498 http://dx.doi.org/10.1186/s40478-023-01559-0 |
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