Pentose Pathway Activation Is Superior to Increased Glycolysis for Therapeutic Angiogenesis in Peripheral Arterial Disease

BACKGROUND: In endothelial cells (ECs), glycolysis, regulated by PFKFB3 (6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase, isoform‐3), is the major metabolic pathway for ATP generation. In preclinical peripheral artery disease models, VEGF(165)a (vascular endothelial growth factor(165)a) and micr...

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Detalles Bibliográficos
Autores principales: Zaied, Abdelrahman A., Ushio‐Fukai, Masuko, Fukai, Tohru, Kovacs‐Kasa, Anita, Alhusban, Suhib, Sudhahar, Varadarajan, Ganta, Vijay C., Annex, Brian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122893/
https://www.ncbi.nlm.nih.gov/pubmed/36974760
http://dx.doi.org/10.1161/JAHA.122.027986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122893/
https://www.ncbi.nlm.nih.gov/pubmed/36974760
http://dx.doi.org/10.1161/JAHA.122.027986

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