New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta

Cardiotoxicity, particularly drug-induced Torsades de Pointes (TdP), is a concern in drug safety assessment. The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (human iPSC-CMs) has become an attractive human-based platform for predicting cardiotoxicity. Moreover,...

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Detalles Bibliográficos
Autores principales: An, Jin Ryeol, Mun, Seo-Yeong, Jung, In Kyo, Kim, Kwan Soo, Kwon, Chan Hyeok, Choi, Sun Ok, Park, Won Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123000/
https://www.ncbi.nlm.nih.gov/pubmed/37078300
http://dx.doi.org/10.4196/kjpp.2023.27.3.267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123000/
https://www.ncbi.nlm.nih.gov/pubmed/37078300
http://dx.doi.org/10.4196/kjpp.2023.27.3.267

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