PRRC2 proteins impact translation initiation by promoting leaky scanning

Roughly half of animal mRNAs contain upstream open reading frames (uORFs). These uORFs can represent an impediment to translation of the main ORF since ribosomes usually bind the mRNA cap at the 5′ end and then scan for ORFs in a 5′-to-3′ fashion. One way for ribosomes to bypass uORFs is via leaky s...

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Detalles Bibliográficos
Autores principales: Bohlen, Jonathan, Roiuk, Mykola, Neff, Marilena, Teleman, Aurelio A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123092/
https://www.ncbi.nlm.nih.gov/pubmed/36869665
http://dx.doi.org/10.1093/nar/gkad135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123092/
https://www.ncbi.nlm.nih.gov/pubmed/36869665
http://dx.doi.org/10.1093/nar/gkad135

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