Design principles and functional basis of enantioselectivity of alanyl-tRNA synthetase and a chiral proofreader during protein biosynthesis

Homochirality of the cellular proteome is attributed to the L-chiral bias of the translation apparatus. The chiral specificity of enzymes was elegantly explained using the ‘four-location’ model by Koshland two decades ago. In accordance with the model, it was envisaged and noted that some aminoacyl-...

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Detalles Bibliográficos
Autores principales: Sivakumar, Koushick, Venkadasamy, Vinitha Lakshmi, Amudhan, Gurumoorthy, Ann, Kezia J, Goud, Gadela Karteek, Nayani, Kiranmai, Gogoi, Jotin, Kuncha, Santosh Kumar, Mainkar, Prathama S, Kruparani, Shobha P, Sankaranarayanan, Rajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123102/
https://www.ncbi.nlm.nih.gov/pubmed/36951106
http://dx.doi.org/10.1093/nar/gkad205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123102/
https://www.ncbi.nlm.nih.gov/pubmed/36951106
http://dx.doi.org/10.1093/nar/gkad205

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