Homologous recombination suppresses transgenerational DNA end resection and chromosomal instability in fission yeast

Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been implicated as a major driver of CIN, however, the underlying mechanism remains unclear. Using a fission yeast model system, we e...

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Detalles Bibliográficos
Autores principales: Pai, Chen-Chun, Durley, Samuel C, Cheng, Wei-Chen, Chiang, Nien-Yi, Peters, Jennifer, Kasparek, Torben, Blaikley, Elizabeth, Wee, Boon-Yu, Walker, Carol, Kearsey, Stephen E, Buffa, Francesca, Murray, Johanne M, Humphrey, Timothy C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123110/
https://www.ncbi.nlm.nih.gov/pubmed/36951111
http://dx.doi.org/10.1093/nar/gkad160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123110/
https://www.ncbi.nlm.nih.gov/pubmed/36951111
http://dx.doi.org/10.1093/nar/gkad160

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