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Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers
Polyglutamine expansion at the N-terminus of the huntingtin protein exon 1 (Htt-ex1) is closely associated with a number of neurodegenerative diseases, which result from the aggregation of the increased polyQ repeat. However, the underlying structures and aggregation mechanism are still poorly under...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123271/ https://www.ncbi.nlm.nih.gov/pubmed/37101557 http://dx.doi.org/10.3389/fmolb.2023.1143353 |