Sirtuin 1 activator alleviated lethal inflammatory injury via promotion of autophagic degradation of pyruvate kinase M2

Upregulation of pyruvate kinase M2 (PKM2) is critical for the orchestration of metabolism and inflammation in critical illness, while autophagic degradation is a recently revealed mechanism that counter-regulates PKM2. Accumulating evidence suggests that sirtuin 1 (SIRT1) function as a crucial regul...

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Detalles Bibliográficos
Autores principales: Zhao, Shuang, Sun, Yili, Wu, Xicheng, Yang, Yongqiang, Fan, Kerui, Hu, Kai, Qin, Yasha, Li, Kexin, Lin, Ling, Chen, Kun, Ma, Yuhua, Zhu, Min, Liu, Gang, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123272/
https://www.ncbi.nlm.nih.gov/pubmed/37101542
http://dx.doi.org/10.3389/fphar.2023.1092943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123272/
https://www.ncbi.nlm.nih.gov/pubmed/37101542
http://dx.doi.org/10.3389/fphar.2023.1092943

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