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Inhibition of Listeria Monocytogenes HtrA Protease with Camostat, Gabexate and Nafamostat Mesylates and the Binding Mode of the Inhibitors

In many bacteria, the High Temperature requirement A (HtrA) protein functions as a chaperone and protease. HtrA is an important factor in stress tolerance and plays a significant role in the virulence of several pathogenic bacteria. Camostat, gabexate and nafamostat mesylates are serine protease inh...

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Detalles Bibliográficos
Autores principales: C, Amrutha M, Wessler, Silja, Ponnuraj, Karthe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10123570/
https://www.ncbi.nlm.nih.gov/pubmed/37093417
http://dx.doi.org/10.1007/s10930-023-10114-8