Activation of Gcn2 by small molecules designed to be inhibitors

The integrated stress response (ISR) is an important mechanism by which cells confer protection against environmental stresses. Central to the ISR is a collection of related protein kinases that monitor stress conditions, such as Gcn2 (EIF2AK4) that recognizes nutrient limitations, inducing phosphor...

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Detalles Bibliográficos
Autores principales: Carlson, Kenneth R., Georgiadis, Millie M., Tameire, Feven, Staschke, Kirk A., Wek, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124904/
https://www.ncbi.nlm.nih.gov/pubmed/36898579
http://dx.doi.org/10.1016/j.jbc.2023.104595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124904/
https://www.ncbi.nlm.nih.gov/pubmed/36898579
http://dx.doi.org/10.1016/j.jbc.2023.104595

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