Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity determining P1 pocket, calls for innovative approaches. Proteomic analysis of cell lysates with human cathepsins K, V, B, L, S, and F identified 30,000 cleavage...

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Detalles Bibliográficos
Autores principales: Tušar, Livija, Loboda, Jure, Impens, Francis, Sosnowski, Piotr, Van Quickelberghe, Emmy, Vidmar, Robert, Demol, Hans, Sedeyn, Koen, Saelens, Xavier, Vizovišek, Matej, Mihelič, Marko, Fonović, Marko, Horvat, Jaka, Kosec, Gregor, Turk, Boris, Gevaert, Kris, Turk, Dušan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124925/
https://www.ncbi.nlm.nih.gov/pubmed/37095140
http://dx.doi.org/10.1038/s42003-023-04772-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124925/
https://www.ncbi.nlm.nih.gov/pubmed/37095140
http://dx.doi.org/10.1038/s42003-023-04772-8

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