Cargando…

Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

Addressing the elusive specificity of cysteine cathepsins, which in contrast to caspases and trypsin-like proteases lack strict specificity determining P1 pocket, calls for innovative approaches. Proteomic analysis of cell lysates with human cathepsins K, V, B, L, S, and F identified 30,000 cleavage...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tušar, Livija, Loboda, Jure, Impens, Francis, Sosnowski, Piotr, Van Quickelberghe, Emmy, Vidmar, Robert, Demol, Hans, Sedeyn, Koen, Saelens, Xavier, Vizovišek, Matej, Mihelič, Marko, Fonović, Marko, Horvat, Jaka, Kosec, Gregor, Turk, Boris, Gevaert, Kris, Turk, Dušan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124925/ https://www.ncbi.nlm.nih.gov/pubmed/37095140 http://dx.doi.org/10.1038/s42003-023-04772-8

Ejemplares similares

SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea
por: Kirm, Benjamin, et al.
Publicado: (2013)

Salivary Tick Cystatin OmC2 Targets Lysosomal Cathepsins S and C in Human Dendritic Cells
por: Zavašnik-Bergant, Tina, et al.
Publicado: (2017)

Integrated omics approaches provide strategies for rapid erythromycin yield increase in Saccharopolyspora erythraea
por: Karničar, Katarina, et al.
Publicado: (2016)

Selective Targeting of Tumor and Stromal Cells By a Nanocarrier System Displaying Lipidated Cathepsin B Inhibitor**
por: Mikhaylov, G, et al.
Publicado: (2014)

The Acute Phase Response Is a Prominent Renal Proteome Change in Sepsis in Mice
por: Róka, Beáta, et al.
Publicado: (2019)

The Structure of Clostridioides difficile SecA2 ATPase Exposes Regions Responsible for Differential Target Recognition of the SecA1 and SecA2-Dependent Systems
por: Lindič, Nataša, et al.
Publicado: (2020)

Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment
por: Vidak, Eva, et al.
Publicado: (2019)

Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells
por: Bernegger, Sabine, et al.
Publicado: (2021)

Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C
por: Poreba, Marcin, et al.
Publicado: (2014)

Mechanisms Applied by Protein Inhibitors to Inhibit Cysteine Proteases
por: Tušar, Livija, et al.
Publicado: (2021)

Cysteine Cathepsin Activity Regulation by Glycosaminoglycans
por: Novinec, Marko, et al.
Publicado: (2014)

Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis – Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva
por: Hočevar, Katarina, et al.
Publicado: (2020)

Time-Dependent miRNA Profile during Septic Acute Kidney Injury in Mice
por: Tod, Pál, et al.
Publicado: (2020)

Profilin 1 as a Target for Cathepsin X Activity in Tumor Cells
por: Pečar Fonović, Urša, et al.
Publicado: (2013)

Cysteine cathepsins: From structure, function and regulation to new frontiers()
por: Turk, Vito, et al.
Publicado: (2012)

Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples
por: Poreba, Marcin, et al.
Publicado: (2019)

Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells
por: Završnik, Janja, et al.
Publicado: (2017)

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes
por: Poreba, Marcin, et al.
Publicado: (2018)

Codon Optimisation Is Key for Pernisine Expression in Escherichia coli
por: Šnajder, Marko, et al.
Publicado: (2015)

Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy
por: Mitrović, Ana, et al.
Publicado: (2022)

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K
por: Mons, Elma, et al.
Publicado: (2019)

In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate**
por: Hu, Hai-Yu, et al.
Publicado: (2014)

Human Stefin B Role in Cell's Response to Misfolded Proteins and Autophagy
por: Polajnar, Mira, et al.
Publicado: (2014)

Circular RNA hsa_circ_0062682 Binds to YBX1 and Promotes Oncogenesis in Hepatocellular Carcinoma
por: Razpotnik, Rok, et al.
Publicado: (2022)

Partial rotational lattice order–disorder in stefin B crystals
por: Renko, Miha, et al.
Publicado: (2014)

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway
por: Van Quickelberghe, Emmy, et al.
Publicado: (2018)

Free kick instead of cross-validation in maximum-likelihood refinement of macromolecular crystal structures
por: Pražnikar, Jure, et al.
Publicado: (2014)

Identification and characterization of the novel reversible and selective cathepsin X inhibitors
por: Fonović, Urša Pečar, et al.
Publicado: (2017)

Validation and quality assessment of macromolecular structures using complex network analysis
por: Pražnikar, Jure, et al.
Publicado: (2019)

A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding
por: Bernegger, Sabine, et al.
Publicado: (2020)

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses
por: Sedeyn, Koen, et al.
Publicado: (2019)

Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis
por: Pečar Fonović, Urša, et al.
Publicado: (2015)

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target
por: Reinheckel, Thomas, et al.
Publicado: (2012)

The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers
por: Mihelič, Marko, et al.
Publicado: (2017)

Comparison of Free-Space and Waveguide-Based SERS Platforms
por: Turk, Nina, et al.
Publicado: (2019)

Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin
por: Kramer, Lovro, et al.
Publicado: (2017)

Improved Cathepsin Probes for Sensitive Molecular Imaging
por: Yitzhak, Yonit, et al.
Publicado: (2022)

Implementation of food matrix effects into chemical food contaminant risk assessment
por: Cioca, Ana‐Andreea, et al.
Publicado: (2022)

Food Risk Analysis: Towards a Better Understanding of “Hazard” and “Risk” in EU Food Legislation
por: Cioca, Ana-Andreea, et al.
Publicado: (2023)

Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors
por: Majc, Bernarda, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_etbslj7cac9vj9b542jpjt0020