Controlling Amyloid Beta Peptide Aggregation and Toxicity by Protease-Stable Ligands

[Image: see text] Polymerization of soluble amyloid beta (Aβ) peptide into protease-stable insoluble fibrillary aggregates is a critical step in the pathogenesis of Alzheimer’s disease (AD). The N-terminal (NT) hydrophobic central domain fragment 16KLVFF20 plays an important role in the formation an...

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Detalles Bibliográficos
Autores principales: Mallesh, Rathnam, Juhee khan, Gharai, Prabir Kumar, Gupta, Varsha, Roy, Rajsekhar, Ghosh, Surajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125337/
https://www.ncbi.nlm.nih.gov/pubmed/37101809
http://dx.doi.org/10.1021/acsbiomedchemau.2c00067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125337/
https://www.ncbi.nlm.nih.gov/pubmed/37101809
http://dx.doi.org/10.1021/acsbiomedchemau.2c00067

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