A human iPSC-derived hepatocyte screen identifies compounds that inhibit production of Apolipoprotein B

Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which can cause severe cardiovascular disease. Statins, bile acid sequestrants, PCSK9 inhibitors, and cholesterol absorption inhibitors are all inefficient at treating FH p...

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Detalles Bibliográficos
Autores principales: Liu, Jui-Tung, Doueiry, Caren, Jiang, Yu-lin, Blaszkiewicz, Josef, Lamprecht, Mary Paige, Heslop, James A., Peterson, Yuri K., Carten, Juliana Debrito, Traktman, Paula, Yuan, Yang, Khetani, Salman R., Twal, Waleed O., Duncan, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125972/
https://www.ncbi.nlm.nih.gov/pubmed/37095219
http://dx.doi.org/10.1038/s42003-023-04739-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125972/
https://www.ncbi.nlm.nih.gov/pubmed/37095219
http://dx.doi.org/10.1038/s42003-023-04739-9

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