In silico cancer immunotherapy trials uncover the consequences of therapy-specific response patterns for clinical trial design and outcome

Late-stage cancer immunotherapy trials often lead to unusual survival curve shapes, like delayed curve separation or a plateauing curve in the treatment arm. It is critical for trial success to anticipate such effects in advance and adjust the design accordingly. Here, we use in silico cancer immuno...

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Detalles Bibliográficos
Autores principales: Creemers, Jeroen H. A., Ankan, Ankur, Roes, Kit C. B., Schröder, Gijs, Mehra, Niven, Figdor, Carl G., de Vries, I. Jolanda M., Textor, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125995/
https://www.ncbi.nlm.nih.gov/pubmed/37095077
http://dx.doi.org/10.1038/s41467-023-37933-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10125995/
https://www.ncbi.nlm.nih.gov/pubmed/37095077
http://dx.doi.org/10.1038/s41467-023-37933-8

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