Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria

Accumulating evidence suggests mitochondria as key modulators of normal and premature aging, yet whether primary oxidative phosphorylation (OXPHOS) deficiency can cause progeroid disease remains unclear. Here, we show that mice with severe isolated respiratory complex III (CIII) deficiency display n...

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Detalles Bibliográficos
Autores principales: Purhonen, Janne, Banerjee, Rishi, Wanne, Vilma, Sipari, Nina, Mörgelin, Matthias, Fellman, Vineta, Kallijärvi, Jukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126100/
https://www.ncbi.nlm.nih.gov/pubmed/37095097
http://dx.doi.org/10.1038/s41467-023-38027-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126100/
https://www.ncbi.nlm.nih.gov/pubmed/37095097
http://dx.doi.org/10.1038/s41467-023-38027-1

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