Evidence for a protective effect of the loss of α4-containing nicotinic acetylcholine receptors on Aβ-related neuropathology in Tg2576 mice

INTRODUCTION: Loss of cholinergic neurons as well as α4β2* (* = containing) nicotinic acetylcholine receptors (nAChRs) is a prominent feature of Alzheimer’s disease (AD). Specifically, amyloid β (Aβ), the principal pathogenic factor of AD, is a high affinity ligand for nAChRs. Yet, the pathophysiolo...

Descripción completa

Detalles Bibliográficos
Autores principales: Vilella, Antonietta, Romoli, Benedetto, Bodria, Martina, Pons, Stéphanie, Maskos, Uwe, Zoli, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126303/
https://www.ncbi.nlm.nih.gov/pubmed/37113156
http://dx.doi.org/10.3389/fnins.2023.1097857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126303/
https://www.ncbi.nlm.nih.gov/pubmed/37113156
http://dx.doi.org/10.3389/fnins.2023.1097857

Ejemplares similares