Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia

OBJECTIVE: This study aimed to evaluate the predictive performance of end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc) values phototherapy in neonates with significant hyperbilirubinemia. METHODS: A prospective study was conducted on neonates with significant hyperbilirubinemia...

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Autores principales: Zhan, Yuan-Li, Peng, Hai-Bo, Jin, Zhen-Chao, Su, Jin-Feng, Tan, Xiang-Yu, Zhao, Lu, Zhang, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126460/
https://www.ncbi.nlm.nih.gov/pubmed/37114002
http://dx.doi.org/10.3389/fped.2023.1154350
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author Zhan, Yuan-Li
Peng, Hai-Bo
Jin, Zhen-Chao
Su, Jin-Feng
Tan, Xiang-Yu
Zhao, Lu
Zhang, Lian
author_facet Zhan, Yuan-Li
Peng, Hai-Bo
Jin, Zhen-Chao
Su, Jin-Feng
Tan, Xiang-Yu
Zhao, Lu
Zhang, Lian
author_sort Zhan, Yuan-Li
collection PubMed
description OBJECTIVE: This study aimed to evaluate the predictive performance of end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc) values phototherapy in neonates with significant hyperbilirubinemia. METHODS: A prospective study was conducted on neonates with significant hyperbilirubinemia who received phototherapy between 3 and 7 days of life. The breath ETCOc and serum total bilirubin of the recruited infants were measured on admission. RESULTS: The mean ETCOc at admission in 103 neonates with significant hyperbilirubinemia was 1.70 ppm. The neonates were categorized into two groups: phototherapy duration ≤72 h (n = 87) and >72 h (n = 16) groups. Infants who received phototherapy for >72 h had significantly higher ETCOc (2.45 vs. 1.60, P = 0.001). The cutoff value of ETCOc on admission for predicting longer phototherapy duration was 2.4 ppm, with a sensitivity of 62.5% and specificity of 88.5%, yielding a 50% positive predictive value and a 92.7% negative predictive value. CONCLUSION: ETCOc on admission can help predict the duration of phototherapy in neonates with hyperbilirubinemia, facilitate clinicians to judge disease severity, and make clinical communication easier and more efficient.
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spelling pubmed-101264602023-04-26 Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia Zhan, Yuan-Li Peng, Hai-Bo Jin, Zhen-Chao Su, Jin-Feng Tan, Xiang-Yu Zhao, Lu Zhang, Lian Front Pediatr Pediatrics OBJECTIVE: This study aimed to evaluate the predictive performance of end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc) values phototherapy in neonates with significant hyperbilirubinemia. METHODS: A prospective study was conducted on neonates with significant hyperbilirubinemia who received phototherapy between 3 and 7 days of life. The breath ETCOc and serum total bilirubin of the recruited infants were measured on admission. RESULTS: The mean ETCOc at admission in 103 neonates with significant hyperbilirubinemia was 1.70 ppm. The neonates were categorized into two groups: phototherapy duration ≤72 h (n = 87) and >72 h (n = 16) groups. Infants who received phototherapy for >72 h had significantly higher ETCOc (2.45 vs. 1.60, P = 0.001). The cutoff value of ETCOc on admission for predicting longer phototherapy duration was 2.4 ppm, with a sensitivity of 62.5% and specificity of 88.5%, yielding a 50% positive predictive value and a 92.7% negative predictive value. CONCLUSION: ETCOc on admission can help predict the duration of phototherapy in neonates with hyperbilirubinemia, facilitate clinicians to judge disease severity, and make clinical communication easier and more efficient. Frontiers Media S.A. 2023-04-11 /pmc/articles/PMC10126460/ /pubmed/37114002 http://dx.doi.org/10.3389/fped.2023.1154350 Text en © 2023 Zhan, Peng, Jin, Su, Tan, Zhao and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Zhan, Yuan-Li
Peng, Hai-Bo
Jin, Zhen-Chao
Su, Jin-Feng
Tan, Xiang-Yu
Zhao, Lu
Zhang, Lian
Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
title Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
title_full Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
title_fullStr Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
title_full_unstemmed Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
title_short Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
title_sort higher etcoc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126460/
https://www.ncbi.nlm.nih.gov/pubmed/37114002
http://dx.doi.org/10.3389/fped.2023.1154350
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