Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia
OBJECTIVE: This study aimed to evaluate the predictive performance of end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc) values phototherapy in neonates with significant hyperbilirubinemia. METHODS: A prospective study was conducted on neonates with significant hyperbilirubinemia...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126460/ https://www.ncbi.nlm.nih.gov/pubmed/37114002 http://dx.doi.org/10.3389/fped.2023.1154350 |
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author | Zhan, Yuan-Li Peng, Hai-Bo Jin, Zhen-Chao Su, Jin-Feng Tan, Xiang-Yu Zhao, Lu Zhang, Lian |
author_facet | Zhan, Yuan-Li Peng, Hai-Bo Jin, Zhen-Chao Su, Jin-Feng Tan, Xiang-Yu Zhao, Lu Zhang, Lian |
author_sort | Zhan, Yuan-Li |
collection | PubMed |
description | OBJECTIVE: This study aimed to evaluate the predictive performance of end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc) values phototherapy in neonates with significant hyperbilirubinemia. METHODS: A prospective study was conducted on neonates with significant hyperbilirubinemia who received phototherapy between 3 and 7 days of life. The breath ETCOc and serum total bilirubin of the recruited infants were measured on admission. RESULTS: The mean ETCOc at admission in 103 neonates with significant hyperbilirubinemia was 1.70 ppm. The neonates were categorized into two groups: phototherapy duration ≤72 h (n = 87) and >72 h (n = 16) groups. Infants who received phototherapy for >72 h had significantly higher ETCOc (2.45 vs. 1.60, P = 0.001). The cutoff value of ETCOc on admission for predicting longer phototherapy duration was 2.4 ppm, with a sensitivity of 62.5% and specificity of 88.5%, yielding a 50% positive predictive value and a 92.7% negative predictive value. CONCLUSION: ETCOc on admission can help predict the duration of phototherapy in neonates with hyperbilirubinemia, facilitate clinicians to judge disease severity, and make clinical communication easier and more efficient. |
format | Online Article Text |
id | pubmed-10126460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101264602023-04-26 Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia Zhan, Yuan-Li Peng, Hai-Bo Jin, Zhen-Chao Su, Jin-Feng Tan, Xiang-Yu Zhao, Lu Zhang, Lian Front Pediatr Pediatrics OBJECTIVE: This study aimed to evaluate the predictive performance of end-tidal carbon monoxide corrected to ambient carbon monoxide (ETCOc) values phototherapy in neonates with significant hyperbilirubinemia. METHODS: A prospective study was conducted on neonates with significant hyperbilirubinemia who received phototherapy between 3 and 7 days of life. The breath ETCOc and serum total bilirubin of the recruited infants were measured on admission. RESULTS: The mean ETCOc at admission in 103 neonates with significant hyperbilirubinemia was 1.70 ppm. The neonates were categorized into two groups: phototherapy duration ≤72 h (n = 87) and >72 h (n = 16) groups. Infants who received phototherapy for >72 h had significantly higher ETCOc (2.45 vs. 1.60, P = 0.001). The cutoff value of ETCOc on admission for predicting longer phototherapy duration was 2.4 ppm, with a sensitivity of 62.5% and specificity of 88.5%, yielding a 50% positive predictive value and a 92.7% negative predictive value. CONCLUSION: ETCOc on admission can help predict the duration of phototherapy in neonates with hyperbilirubinemia, facilitate clinicians to judge disease severity, and make clinical communication easier and more efficient. Frontiers Media S.A. 2023-04-11 /pmc/articles/PMC10126460/ /pubmed/37114002 http://dx.doi.org/10.3389/fped.2023.1154350 Text en © 2023 Zhan, Peng, Jin, Su, Tan, Zhao and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Zhan, Yuan-Li Peng, Hai-Bo Jin, Zhen-Chao Su, Jin-Feng Tan, Xiang-Yu Zhao, Lu Zhang, Lian Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia |
title | Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia |
title_full | Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia |
title_fullStr | Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia |
title_full_unstemmed | Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia |
title_short | Higher ETCOc predicts longer phototherapy treatment in neonatal hyperbilirubinemia |
title_sort | higher etcoc predicts longer phototherapy treatment in neonatal hyperbilirubinemia |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126460/ https://www.ncbi.nlm.nih.gov/pubmed/37114002 http://dx.doi.org/10.3389/fped.2023.1154350 |
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