Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Vascular mechanisms of Alzheimer’s disease (AD) may constitute a therapeutically addressable biological pathway underlying dementia. We previously demonstrated that soluble pathogenic forms of tau (tau oligomers) accumulate in brain microvasculature of AD and other tauopathies, including prominently...

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Detalles Bibliográficos
Autores principales: Hussong, Stacy A., Banh, Andy Q., Van Skike, Candice E., Dorigatti, Angela O., Hernandez, Stephen F., Hart, Matthew J., Ferran, Beatriz, Makhlouf, Haneen, Gaczynska, Maria, Osmulski, Pawel A., McAllen, Salome A., Dineley, Kelly T., Ungvari, Zoltan, Perez, Viviana I., Kayed, Rakez, Galvan, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126555/
https://www.ncbi.nlm.nih.gov/pubmed/37185259
http://dx.doi.org/10.1038/s41467-023-37840-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126555/
https://www.ncbi.nlm.nih.gov/pubmed/37185259
http://dx.doi.org/10.1038/s41467-023-37840-y

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