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Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning

Background: De novo protein coding genes emerge from scratch in the non-coding regions of the genome and have, per definition, no homology to other genes. Therefore, their encoded de novo proteins belong to the so-called "dark protein space". So far, only four de novo protein structures ha...

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Detalles Bibliográficos
Autores principales: Aubel, Margaux, Eicholt, Lars, Bornberg-Bauer, Erich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126731/
https://www.ncbi.nlm.nih.gov/pubmed/37113259
http://dx.doi.org/10.12688/f1000research.130443.1