Cargando…

Gain‑of‑function of IDO in DCs inhibits T cell immunity by metabolically regulating surface molecules and cytokines

Both tolerogenicity and immunogenicity of dendritic cells (DCs) are regulated by their intracellular metabolism. As a rate-limiting enzyme of tryptophan (Trp) metabolism, indoleamine 2,3-dioxygenase (IDO) is involved in regulating the functions of numerous cell types, including DCs, a subset of whic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Fengge, Liu, Lei, Wang, Juncheng, Liu, Meng, Zhang, Wenjie, Zhao, Lin, Zhai, Chengfeng, Xu, Yuekang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126813/ https://www.ncbi.nlm.nih.gov/pubmed/37114180 http://dx.doi.org/10.3892/etm.2023.11933

Ejemplares similares

IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
por: Lippens, Carla, et al.
Publicado: (2016)

PGE(2)-Induced IDO1 Inhibits the Capacity of Fully Mature DCs to Elicit an In Vitro Antileukemic Immune Response
por: Trabanelli, Sara, et al.
Publicado: (2015)

Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead
por: Sun, Li, et al.
Publicado: (2020)

IL-10(−/−) Enhances DCs Immunity Against Chlamydia psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways
por: Li, Qiang, et al.
Publicado: (2021)

Indoleamine 2,3-Dioxygenase (IDO) Downregulates the Cell Surface Expression of the CD4 Molecule
por: Huang, Guanyou, et al.
Publicado: (2012)

Self-Tolerance of Vascular Tissues Is Broken Down by Vascular Dendritic Cells in Response to Systemic Inflammation to Initiate Regional Autoinflammation
por: Sun, Li, et al.
Publicado: (2022)

Impact of IDO1 and IDO2 on the B Cell Immune Response
por: Merlo, Lauren M. F., et al.
Publicado: (2022)

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses
por: Merlo, Lauren M. F., et al.
Publicado: (2020)

USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
por: Shi, Dongni, et al.
Publicado: (2022)

The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS
por: Kashi, Alex A., et al.
Publicado: (2019)

Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma
por: Zhai, Lijie, et al.
Publicado: (2021)

IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma
por: Liu, Hongmei, et al.
Publicado: (2022)

Targeting the IDO1 pathway in cancer: from bench to bedside
por: Liu, Ming, et al.
Publicado: (2018)

Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis
por: Zhang, Shengchao, et al.
Publicado: (2021)

Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo
por: Ge, Shushan, et al.
Publicado: (2020)

Task demands, tDCS intensity, and the COMT val(158)met polymorphism impact tDCS-linked working memory training gains
por: Stephens, Jaclyn A., et al.
Publicado: (2017)

Editorial: Adaptive immunity in local tissues
por: Zhang, Wenjie, et al.
Publicado: (2023)

Amyloid β neurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor
por: Duan, Zhenzhen, et al.
Publicado: (2020)

The Effect of Mesenchymal Stem Cells on the Expression of IDO and Qa2 Molecules in Dendritic Cells
por: Moravej, Ali, et al.
Publicado: (2019)

Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2
por: Lee, Young-Kwan, et al.
Publicado: (2014)

Anodal tDCS applied during multitasking training leads to transferable performance gains
por: Filmer, Hannah L., et al.
Publicado: (2017)

Galectin 3 protects from cisplatin-induced acute kidney injury by promoting TLR-2-dependent activation of IDO1/Kynurenine pathway in renal DCs
por: Volarevic, Vladislav, et al.
Publicado: (2019)

IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status
por: Nandre, Rahul, et al.
Publicado: (2022)

Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration
por: Zong, Shanshan, et al.
Publicado: (2016)

Efficient Maturation and Cytokine Production of Neonatal DCs Requires Combined Proinflammatory Signals
por: Krumbiegel, Doreen, et al.
Publicado: (2005)

IDO in Colorectal Tumorigenesis: Involvement of Immune Tolerance and Significance in Prevention and Therapy
por: Tang, Shunan, et al.
Publicado: (2021)

Genetic Polymorphisms Affecting IDO1 or IDO2 Activity Differently Associate With Aspergillosis in Humans
por: Napolioni, Valerio, et al.
Publicado: (2019)

Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells
por: Marttila, Saara, et al.
Publicado: (2011)

The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance during Pregnancy in the Mouse
por: Fang, Wen-ning, et al.
Publicado: (2016)

Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19
por: Guo, Lihui, et al.
Publicado: (2022)

Data on PRRSV infection promoted the subtype of porcine dendritic cells from mDCs to pDCs in vivo
por: Liu, Jinling, et al.
Publicado: (2016)

Identification of an IDO1‐based immune classifier for survival prediction of upper tract urothelial carcinoma
por: Zhong, Wenlong, et al.
Publicado: (2022)

The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs
por: Zhang, Cheng, et al.
Publicado: (2017)

CD4 responses against IDO
por: Andersen, Mads Hald
Publicado: (2012)

IDO-GCN2 and autophagy in inflammation
por: McGaha, Tracy L.
Publicado: (2015)

IDO2 in Immunomodulation and Autoimmune Disease
por: Prendergast, George C., et al.
Publicado: (2014)

IDO1 and IDO2 Non-Synonymous Gene Variants: Correlation with Crohn's Disease Risk and Clinical Phenotype
por: Lee, Alexander, et al.
Publicado: (2014)

The Effect of IDO on Neural Progenitor Cell Survival Under Oxygen Glucose Deprivation
por: Wang, Jixian, et al.
Publicado: (2020)

IDO1 Promotes the Progression of NSCLC by Regulating the Polarization of M2 Macrophages
por: Chen, Xiao, et al.
Publicado: (2023)

During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk
por: Guo, Yahui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1m26hljja7ee1vbqldqq5rmt2a