Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs

Messenger RNA (mRNA)-based gene delivery is a powerful strategy for the development of vaccines and therapeutics. Consequently, approaches that enable efficient synthesis of mRNAs with high purity and biological activity are in demand. Chemically modified 7-methylguanosine (m(7)G) 5′ caps can augmen...

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Detalles Bibliográficos
Autores principales: Kozarski, Mateusz, Drazkowska, Karolina, Bednarczyk, Marcelina, Warminski, Marcin, Jemielity, Jacek, Kowalska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126820/
https://www.ncbi.nlm.nih.gov/pubmed/37114020
http://dx.doi.org/10.1039/d3ra00026e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126820/
https://www.ncbi.nlm.nih.gov/pubmed/37114020
http://dx.doi.org/10.1039/d3ra00026e

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