Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its function. Computational analysis of the amino acid sequence of NCAP reveals low-complexity domains (LCDs) akin to LCDs in other proteins known to self-assemble as phase separation droplets and amyloid fibrils. Prev...

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Detalles Bibliográficos
Autores principales: Tayeb-Fligelman, Einav, Bowler, Jeannette T., Tai, Christen E., Sawaya, Michael R., Jiang, Yi Xiao, Garcia, Gustavo, Griner, Sarah L., Cheng, Xinyi, Salwinski, Lukasz, Lutter, Liisa, Seidler, Paul M., Lu, Jiahui, Rosenberg, Gregory M., Hou, Ke, Abskharon, Romany, Pan, Hope, Zee, Chih-Te, Boyer, David R., Li, Yan, Anderson, Daniel H., Murray, Kevin A., Falcon, Genesis, Cascio, Duilio, Saelices, Lorena, Damoiseaux, Robert, Arumugaswami, Vaithilingaraja, Guo, Feng, Eisenberg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127185/
https://www.ncbi.nlm.nih.gov/pubmed/37185252
http://dx.doi.org/10.1038/s41467-023-37865-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127185/
https://www.ncbi.nlm.nih.gov/pubmed/37185252
http://dx.doi.org/10.1038/s41467-023-37865-3

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