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Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway

[Image: see text] Pseudouridimycin is a microbial C-nucleoside natural product that specifically inhibits bacterial RNA polymerases by binding to the active site and competing with uridine triphosphate for the nucleoside triphosphate (NTP) addition site. Pseudouridimycin consists of 5′-aminopseudour...

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Detalles Bibliográficos
Autores principales: Artukka, Erika, Schnell, Robert, Palmu, Kaisa, Rosenqvist, Petja, Szodorai, Edit, Niemi, Jarmo, Virta, Pasi, Schneider, Gunter, Metsä-Ketelä, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127198/
https://www.ncbi.nlm.nih.gov/pubmed/37005433
http://dx.doi.org/10.1021/acschembio.2c00826