Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation

Huntington's disease (HD) is a neurodegenerative disease resulting from an expansion of the polyglutamine (polyQ) domain within the huntingtin protein (htt). PolyQ expansion triggers toxic aggregation and alters htt/lipid interactions. The first 17 amino acids at the N‐terminus of htt (Nt17) ha...

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Detalles Bibliográficos
Autores principales: Stonebraker, Alyssa R., Beasley, Maryssa, Massinople, Sophia, Wunder, Michelle, Li, Peng, Valentine, Stephen J., Legleiter, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127259/
https://www.ncbi.nlm.nih.gov/pubmed/37052951
http://dx.doi.org/10.1002/pro.4642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127259/
https://www.ncbi.nlm.nih.gov/pubmed/37052951
http://dx.doi.org/10.1002/pro.4642

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